CogniSHIELD Global today introduced CogniSHIELD® ADVANCED, a dietary supplement that combines three ingredients developed in the Neuroscience Laboratories at Massachusetts General Hospital with clinically proven Cognizin® Citicoline, the most clinically studied and most bioavailable form of choline. CogniSHIELD ADVANCED is designed to support memory, recall, focus, mental processing speed and healthy cognitive function for people engaged in proactive strategies to support their brain health.* The new formula is available through the CogniSHIELD website and on Amazon and will be the subject of a clinical study in early 2027.

Neuroscientists at Massachusetts General Hospital (MGH) selected three of CogniSHIELD ADVANCED’s ingredients using a laboratory model of key features of the aging brain’s biology. As described in Molecular Neurodegeneration,1 the MGH aging brain model recreates the top biological drivers of brain aging, which allowed researchers to evaluate more than 2000 FDA-approved drugs and 4,000 natural products for their impact on brain health. This work led to the discovery of CogniSHIELD’s original three ingredients—fisetin, ipriflavone and quercetin—and more than 50 additional combinations for investigation. CogniSHIELD Global’s scientific team added Cognizin® Citicoline, the only citicoline studied in healthy adults and supported by 10 human clinical trials, to create CogniSHIELD ADVANCED.

“The research and clinical studies supporting CogniSHIELD ADVANCED’s ingredients reflect our commitment to delivering a dietary supplement with science-backed support for brain health,” said Yuan-Di Halverson, Ph.D., Chief Scientific Officer for CogniSHIELD Global. “The synergistic blend of three ingredients discovered in the Neuroscience Laboratories at Massachusetts General Hospital paired with the most clinically studied and most bioavailable form of choline, Cognizin® Citicoline, supports our science-first approach.”

A science-backed brain health supplement with four active ingredients

CogniSHIELD ADVANCED is a science-backed formula for adults seeking nutritional support for healthy brain aging. * Described below, its four active ingredients have well-understood safety profiles, aging-related benefits and are sourced in nature.

  1. Cognizin Citicoline is the only citicoline studied in healthy adults and supported by 10 human clinical trials. Citicoline is found naturally in every cell of the body, is especially vital to the brain and can be accessed by consuming foods rich in phospholipids such as egg yolks, beef liver and legumes. It can be difficult to get enough citicoline from diet alone.

  2. Fisetin is a plant flavonoid reported to be an active phytochemical with a broad range of potential health benefits upon inflammation and oxidative stress. Studies suggest that fisetin reduces phosphorylated tau (p-tau) levels with neuroprotective effects in animal models. Found in foods like strawberries and apples, CogniSHIELD ADVANCED includes the amount found in one serving of either fruit.

  3. Ipriflavone is a flavonoid compound found in trace amounts in leguminous plants and soy products. It has been shown to improve brain cell health in laboratory models and has been widely used to support bone health for decades.

  4. Quercetin is a powerful antioxidant flavonoid found in red onion and many fruits, vegetables and grains. Research has shown its potential health benefits based on its antioxidant, anti-inflammatory, and neuroprotective properties. Using the MGH aging brain model, quercetin was shown to decrease neuroinflammation.

  5. Fenugreek seed powder is specially formulated together with Fisetin and Quercetin to increase the bioavailability of these CogniSHIELD Advanced ingredients.

CogniSHIELD ADVANCED is available at cognishield.com and on Amazon. It comes in a gluten-free, vegan tablet manufactured in a Good Manufacturing Practices (GMP)-certified lab in North America that incorporates the highest quality standards. An ISO-certified lab tests every product batch for potency, safety and purity. The dietary supplement contains no genetically modified ingredients, preservatives or other additives. A one-month supply is $59.99.

About CogniSHIELD Global

Boston-based CogniSHIELD Global helps people support their brain health. Its science-based supplement, CogniSHIELD® ADVANCED, was built on the formulation discovered in the Neuroscience Laboratories of Massachusetts General Hospital and includes Cognizin® Citicoline, one of the most clinically studied forms of citicoline. The dietary supplement is designed to support memory, recall, focus, mental processing speed and healthy cognitive function.* For more information, visit www.CogniSHIELD.com and follow the company on Instagram, Facebook and LinkedIn.

*CogniSHIELD® ADVANCED is a dietary supplement. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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1 Choi SH, Kim YH, Quinti L, Tanzi RE, Kim DY. Molecular Neurodegeneration. 2016;11:75. https://doi.org/10.1186/s13024-016-0139-7

 

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